Serum survivin is decreased in women with preeclampsia

Guralp O., Gok K., Tuten N., Hamzaoglu K., Makul M., Oner Y. O., ...Daha Fazla

HYPERTENSION IN PREGNANCY, cilt.40, sa.2, ss.144-151, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/10641955.2021.1917601
  • Dergi Adı: HYPERTENSION IN PREGNANCY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.144-151
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Objective: To evaluate the serum survivin level in preeclampsia. Methods: Eighty-eight pregnancies complicated with preeclampsia and 88 gestational-age (GA)-matched uncomplicated pregnancies were evaluated. Results: Mean serum survivin was detected to be significantly decreased in the early- (EOPE) and late-onset (LOPE) preeclampsia subgroups than the GA-matched control-groups; and were comparable in EOPE- and LOPE-groups after correction for GA. Serum survivin had weak negative correlations with systolic and diastolic arterial blood pressure. Conclusion: The serum survivin level was decreased in preeclamptic patients than the GA-matched controls. More comprehensive studies are needed to clarify the timing and extent of placental apoptosis in preeclampsia.