Association of matrix metalloproteinase-1 (MMP-1) promoter region polymorphism with ovarian cancer Ovaryum kanseri ve matriks metalloproteinaz-1 promotör bölge polimorfizmi arasindaki i̇lişki

Diker E., ÖZTÜRK SEZGİN M., ARVAS M. B., Çaǧatay P., Kösebay D.

Jinekoloji ve Obstetrik Dergisi, cilt.20, sa.4, ss.207-212, 2006 (Scopus, TRDizin) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 4
  • Basım Tarihi: 2006
  • Dergi Adı: Jinekoloji ve Obstetrik Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.207-212
  • Anahtar Kelimeler: MMP-1 promoter polymorphism, Ovarian cancer
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

AIM: In this study, the aim was to determine if there is an association between matrix metalloprotcinase-1 (MMP-1) gene promoter polymorphism and ovarian cancer. STUDY DESING: The blood samples were collected from 42 cases of ovarian cancer and from 43 aged matched control subject. PCR and RFLP tecniques were used to determine insertion-deletion (2G/1G) polymorphism in MMP-1 promoter. RESULTS: Genotype frequencies were 2G/2G 78.6 %; 2G/G 21.4 %; G/G % 0 in the patients and 2G/2G 79.1 %; 2G/G 20.9 %: G/G 0 % in the healthy controls. The genotypes did not differ between cases and controls (p>0.05). The distribution of genotypes was in Hardy-Weinherg equilibrium. Allele frequencies were 89.5 % in controls and 89.3 % in cases for 2G allel. There was no relationship between MMP-1 genotype and tumor behavior (invasive-borderline) or tumor stage (early-advance). CONCLUSION: The results show that there was no relationship between MMP-1 promoter polymorphism and ovarian cancer in Turkish population.