Early wound excision and skin grafting restores cellular immunity after severe burn trauma

CETINKALE O., ULUALP K., AYAN F., DUREN M., CIZMECI O., PUSANE A.

British Journal of Surgery, vol.80, no.10, pp.1296-1298, 1993 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 80 Issue: 10
  • Publication Date: 1993
  • Doi Number: 10.1002/bjs.1800801025
  • Journal Name: British Journal of Surgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1296-1298
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Suppression of cellular immunity following thermal injury may contribute to the high incidence of postburn sepsis. Early excision and skin grafting may remove deleterious local wound factors and prevent immunosuppression. The effect on cellular immunity of early burn wound excision and skin grafting was investigated in an animal model using female Wistar rats. The development of immunosuppression shortly after burn injury was shown by popliteal lymph node assay and a 2,4‐dinitrofluorobenzene skin reaction test. Excision and skin grafting 2 days after burn trauma restored parameters to normal. Burned tissue suppresses cellular immunity; this effect is preventable by early excision and skin grafting. Copyright © 1993 British Journal of Surgery Society Ltd.