Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype

Lowery, Maeve; Jordan, Emmet; Basturk, Olca; Ptashkin, Ryan; Zehir, Ahmet; Berger, Michael; Leach, Tanisha; Herbst, Brian; Askan, GÖKÇE; Maynard, Hannah; Glassman, Danielle; Covington, Christina; Schultz, Nikolaus; Abou-Alfa, Ghassan; Harding, James; Klimstra, David; Hechtman, Jaclyn; Hyman, David; Allen, Peter; Jarnagin, William; Balachandran, Vinod; Varghese, Anna; Schattner, Mark; Yu, Kenneth; Saltz, Leonard; Solit, David; Iacobuzio-Donahue, Christine; Leach, Steven; O'Reilly, Eileen

doi:10.1158/1078-0432.ccr-17-0899

Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype

Lowery M. A., Jordan E. J., Basturk O., Ptashkin R. N., Zehir A., Berger M. F., ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.23, sa.20, ss.6094-6100, 2017 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 23 Sayı: 20
Basım Tarihi: 2017
Doi Numarası: 10.1158/1078-0432.ccr-17-0899
Dergi Adı: CLINICAL CANCER RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.6094-6100
İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Purpose: Molecular profiling in cancer has identified potential actionable drug targets that have prompted attempts to discover clinically validated biomarkers to guide therapeutic decision-making and enrollment to clinical trials. We evaluated whether comprehensive genetic analysis of patients with pancreatic adenocarcinoma is feasible within a clinically relevant timeframe and whether such analyses provide predictive and/or prognostic information along with identification of potential targets for therapy.