Chronic Rhinosinusitis in Patients with Primary Immunodeficiency.

Karadeniz E. B., Aliyeva C., Aydemir S., Karaaslan B. G., Mustu U., Ada M., ...Daha Fazla

International archives of allergy and immunology, cilt.184, sa.3, ss.302-310, 2023 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 184 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1159/000527265
  • Dergi Adı: International archives of allergy and immunology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.302-310
  • Anahtar Kelimeler: ECT, depression, nitrosative stress, nitric oxide, nitric oxide synthase, peroxynitrite, NITRIC-OXIDE SYNTHASE, SYMPTOM SEVERITY, GENE-EXPRESSION, ANTIDEPRESSANTS, PATHOPHYSIOLOGY, STIMULATION, MECHANISM, APOPTOSIS, PATHWAYS, DISORDER
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background Few studies have investigated the relationship between electroconvulsive therapy (ECT) and markers of nitrosative stress and oxidative DNA damage. Objective The aim of this study is to examine changes in nitrosative stress and oxidative DNA damage in patients with a depressive episode treated with ECT. Methods The current study included 48 patients with a depressive episode treated with ECT and 30 healthy control participants. First, the serum nitrosative stress markers of nitric oxide (NO center dot), nitric oxide synthase (NOS), and peroxynitrite (ONOO-) and the oxidative DNA damage marker 8-hydroxy-2 '-deoxyguanosine (8-OHdG) were compared between the study and control groups. These parameters were also compared pre- and post-treatment for the study group. Results NO center dot, NOS, and ONOO- levels were significantly higher in patients with depressive disorder (DD) than in the control group. NO center dot and NOS levels significantly decreased in the ECT group after treatment while 8-OHdG levels significantly increased. Conclusions The study findings suggest that ECT may have reduced nitrosative stress levels while increasing oxidative DNA damage. More research is now needed to better understand the issue.