The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey

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Jeyaratnam J., ter Haar N. M., Lachmann H. J., Kasapcopur O., Ombrello A. K., Rigante D., ...More

PEDIATRIC RHEUMATOLOGY, vol.16, 2018 (SCI-Expanded, Scopus)

• Publication Type: Article / Article
• Volume: 16
• Publication Date: 2018
• Doi Number: 10.1186/s12969-018-0235-z
• Journal Name: PEDIATRIC RHEUMATOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Keywords: Autoinflammatory diseases, Live-attenuated vaccines, Biologicals, IL-1 blockade, IL-6 blockade, JUVENILE IDIOPATHIC ARTHRITIS, AUTOINFLAMMATORY DISEASES, EUROFEVER REGISTRY, RECOMMENDATIONS, VACCINATION, MANAGEMENT, TRIAL
• Open Archive Collection: AVESIS Open Access Collection
• Istanbul University-Cerrahpasa Affiliated: No

Abstract

Background: Withholding live-attenuated vaccines in patients using interleukin (IL)-1 or IL-6 blocking agents is recommended by guidelines for both pediatric and adult rheumatic diseases, since there is a risk of infection in an immune suppressed host. However, this has never been studied. This retrospective, multicenter survey aimed to evaluate the safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade.