Beneficial Effects of Rosuvastatin Treatment in Patients With Metabolic Syndrome

Bostan C., Yildiz A., Ozkan A. A., Uzunhasan I., Kaya A., Yigit Z.

ANGIOLOGY, cilt.66, sa.2, ss.122-127, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/0003319714522107
  • Dergi Adı: ANGIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.122-127
  • Anahtar Kelimeler: metabolic syndrome, rosuvastatin, cholesterol subgroups, oxidative stress, DENSITY-LIPOPROTEIN PARTICLES, CHOLESTEROL EDUCATION-PROGRAM, CORONARY-ARTERY-DISEASE, OXIDATIVE STRESS, CLINICAL-SIGNIFICANCE, LDL SUBCLASSES, EUROPEAN PANEL, RISK-FACTORS, SIZE, INFLAMMATION
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

We determined the effect of 6-month rosuvastatin treatment on blood lipids, oxidative parameters, apolipoproteins, high-sensitivity C-reactive protein, lipoprotein(a), homocysteine, and glycated hemoglobin (HbA(1c)) in patients with metabolic syndrome (MetS). Healthy individuals (men aged >40 years and postmenopausal women) with a body mass index 30 (n = 100) who fulfilled the National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria for MetS were included. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels decreased (P < .0001). The change in LDL 1 to 3 subgroups was significant (P = .0007, P < .0001, and P = .006, respectively). Changes in LDL 4 to 7 subgroups were not significant. There was a beneficial effect on oxidized LDL, fibrinogen, homocysteine, and HbA(1c). Rosuvastatin significantly increased high-density lipoprotein levels (P = .0003). The oxidant/antioxidant status and subclinical inflammatory state were also beneficially changed. Rosuvastatin had a significant beneficial effect on atherogenic dyslipidemia as well as on oxidative stress and inflammatory biomarkers in patients with MetS.