Akademik Veri Yönetim Sistemi
HELLENIC JOURNAL OF NUCLEAR MEDICINE, cilt.23, sa.3, ss.321-329, 2020 (SCI-Expanded, Scopus)
Objective: Medullary thyroid cancer (MTC) is an aggressive form of thyroid malignancy with local metastasis in 30%-50% of the cases and distant metastasis predominantly to lung, liver and skeleton in 13%-15% of patients. Identification of the lesion using imaging modalities is of crucial importancefordisease management in the recurrent or metastatic MTC. In this study, we aimed to determine the efficacy of fluorine18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) and gallium-68 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid tyrosine-3-octreotate (Ga-68-DOTATATE) PET/CT imaging in patients with MTC and to evaluate the relationship between imaging findings and serum tumor markers. Materials and Methods: The records of MTC patients, who were treated and followed-up in our department between the years 2005 and 2018 were retrospectively analyzed. Seventythree patients with MTC, who underwent either Ga-68-DOTATATE PET/CT (n=61) and/or F-18-FDG PET/CT (n=59) together with serum calcitonin (Ctn) and/or carcinoembryogenic antigen (CEA) measurement within 6 months period were included in the study. Gallium-68-DOTATATE PET/CT and F-18-FDG PET/CT scans performed within 6 months on the same patient (n=38) were analyzed separately for comparison of the efficacy of both modalities. Results: The overall sensitivity of F-18-FDG PET/CT and Ga-68-DOTATATE PET/CT were 72.4% and 88.1%, respectively in detecting recurrent or metastatic disease. In the group of patients, who had both F-18-FDG PET/CT and Ga-68-DOTATATE PET/CT within 6 months interval (median: 1.14 months; range: 0.03-5.7 months), no significant difference was found in the overall sensitivity of both imaging modalities, however Ga-68-DOTATATE PET/CT was found to be more sensitive in detection of bone lesions compared to F-18-FDG PET/CT (P=0.005). Conclusion: Both F-18-FDG PET/CT and Ga-68-DOTATATE PET/CT are efficient imaging modalities in detection of recurrent or metastatic disease in MTC patients. Gallium-68-DOTATATE PET/CT could be more beneficial in detection of bone metastases with respect to F-18-FDG PET/CT.