SYNTHESIS, EVALUATION OF ANTIFUNGAL ACTIVITY AND DRUG-LIKENESS OF BENZOYL THIOUREA DERIVATIVES

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Erol Günal Ş., Kaplan E.

İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi, vol.24, no.47, pp.217-228, 2025 (Peer-Reviewed Journal)

• Publication Type: Article / Article
• Volume: 24 Issue: 47
• Publication Date: 2025
• Doi Number: 10.55071/ticaretfbd.1588118
• Journal Name: İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi
• Page Numbers: pp.217-228
• Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Herein, we report the synthesis of a series of 2-

bromobenzoyl-substituted thiourea derivatives. The

structures of the synthesized thioureas were characterized

by spectroscopic methods. These derivatives, together

with 2-fluorobenzoyl thioureas synthesized previously,

have been evaluated for their potential antifungal activity.

Compounds 2d and 2f showed antifungal activity against

Candida albicans. Compound 2f also demonstrated

activity against C. parapsilosis. Drug-likeness properties

of the compounds were also estimated, and it was found

that all compounds showed good drug-likeness properties.