POSITIVE AIRWAY PRESSURE NORMALIZES GLUCOSE METABOLISM IN OBSTRUCTIVE SLEEP APNEA INDEPENDENT OF DIABETES AND OBESITY

Kabeloğlu V., Senel G., Karadeniz D.

IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE, cilt.73, ss.417-425, 2020 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73
  • Basım Tarihi: 2020
  • Doi Numarası: 10.18071/isz.73.0417
  • Dergi Adı: IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.417-425
  • Anahtar Kelimeler: obstructive sleep apnea syndrome, positive airway pressure therapy, glucose metabolism, type 2 diabetes mellitus, obesity, RANDOMIZED CONTROLLED-TRIAL, GLYCEMIC CONTROL, INSULIN-RESISTANCE, CPAP, TOLERANCE, RISK, MEN
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background and purpose - The relationship among obstructive sleep apnea syndrome (OSAS), type 2 diabetes mellitus (DM2) and obesity is very complex and multidirectional. Obesity and increased visceral fat are important perpetuating factors for DM2 in patients with OSAS. On the other hand, OSAS itself leads to obesity by causing both leptin and insulin resistance as a consequence of activation of the sympathetic nervous system. Risk for developing DM2 further increases in patients with OSAS and obesity. Data regarding effects of positive airway pressure (PAP) therapy, gold standard treatment for OSAS, on glycemic control were inconsistent due to variability in duration of and adherence to PAP therapy. In our cohort study we investigated effects of PAP treatment on glucose metabolism in normal-weighted non-diabetic OSAS patients, in obese non-diabetic OSAS patients, and in OSAS patients with DM2.