Y-90 Microsphere Radioembolization Dosimetry Y-90 Mikroküre Radyoembolizasyon Dozimetri Kılavuzu

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KOVAN B., Medyenoğlu M., DEMİR M., ÖZDEMİR S.

Nuclear Medicine Seminars, vol.11, no.1, pp.39-47, 2025 (Scopus) identifier

  • Publication Type: Article / Review
  • Volume: 11 Issue: 1
  • Publication Date: 2025
  • Doi Number: 10.4274/nts.galenos.2025.03521
  • Journal Name: Nuclear Medicine Seminars
  • Journal Indexes: Scopus, Academic Search Premier
  • Page Numbers: pp.39-47
  • Keywords: Y-90 dosimetry, Y-90 microsphere dosimetry, Y-90 radioembolization treatment dosimetry
  • Open Archive Collection: AVESIS Open Access Collection
  • Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

The need for dosimetric calculations has arisen to enhance the therapeutic efficacy of Yttrium-90 (Y-90) microsphere therapy, determine tumor absorbed dose threshold values, and accurately identify lung tolerance dose thresholds and liver toxicity thresholds. In microsphere therapies, there are three different dosimetry approaches: standard dosimetry, multicompartment dosimetry, and voxel-based dosimetry. Dosimetric procedures are generally performed using Technetium-99m macroaggregated albumin. However, dosimetry based on scintigraphic images obtained from positron emission tomography/computed tomography (CT) or single photon emission computerized tomography/CT after Y-90 administration is also feasible.