High rate of aneuploidy in luteinized granulosa cells obtained from follicular fluid in women who underwent controlled ovarian hyperstimulation

Kaleli S., Yanikkaya-Demirel G., Erel C. T., Senturk L., Topcuoglu A., Irez T.

FERTILITY AND STERILITY, cilt.84, sa.3, ss.802-804, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 84 Sayı: 3
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.fertnstert.2005.02.040
  • Dergi Adı: FERTILITY AND STERILITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.802-804
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

We performed a prospective study to detect the cell cycle changes in luteinized granulosa cells in patients undergoing controlled ovarian stimulation with GnRH analog and gonadotropin therapy. Aneuploid DNA content was observed in 37 of 70 women (52.9%), and multiple logistic regression analysis revealed that only the dose of gonadotropins used significantly predicted the ploidy status of granulosa cells, which indicates that ovarian hyperstimulation in IVF treatment might be detrimental for the DNA content of granulosa cells.