Copeptin concentrations are not elevated in gestational diabetes mellitus

Oncul M., Tuten A., Kucur M., Imamoglu M., Ekmekci O. B., Acikgoz A. S., ...Daha Fazla

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, sa.5, ss.1045-1049, 2013 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00404-013-2887-8
  • Dergi Adı: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1045-1049
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

To investigate copeptin levels in women with GDM and women with uncomplicated pregnancies. This case-control study was conducted on 45 women with GDM and 40 women with uncomplicated pregnancies. The maternal serum levels of copeptin were measured with enzyme-linked immunosorbent assay. Copeptin levels were not different among groups (0.93 +/- A 0.75 vs. 1.15 +/- A 0.93 ng/ml, p: 0.24). HOMA-IR and insulin levels were significantly higher in woman with GDM when compared with control group (2.90 +/- A 1.88 vs. 1.91 +/- A 0.50, p: 0.002; 11.74 +/- A 6.43 vs. 8.52 +/- A 2.28, p: 0.004, respectively). The copeptin concentrations were significantly correlated with insulin levels and HOMA-IR values (r = 0.329 p = 0.002, r = 0.289 p = 0.007, respectively). The present study shows that serum copeptin concentrations did not differ in woman with GDM and non-GDM patients. However, we found a significant correlation between copeptin and HOMA-IR. Future studies are needed with larger populations in gestational diabetic patients on copeptin secretion, metabolism and action.