Akademik Veri Yönetim Sistemi
JOURNAL OF MOLECULAR STRUCTURE, cilt.1355, sa.144991, ss.144991, 2026 (SCI-Expanded, Scopus)
In this study, three novel Zn(II) complexes (C1-C3) with the general formula [Zn(L1-L3)(EtOH)(H₂O)] were synthesized from asymmetric isatin bisthiocarbohydrazones (L1-L3) to evaluate their potential enzyme inhibitory activities. The compounds were characterized using FT-IR, 1H NMR, UV-Vis spectroscopy, elemental analysis and thermogravimetric analysis (TGA). Spectroscopic and thermogravimetric data indicate that the Zn(II) ion is coordinated through azomethine nitrogen, thiol sulfur and phenolic oxygen donor atoms, along with one water and one ethanol molecule. The ligands and complexes were evaluated for their inhibitory activities against α-amylase, α-glucosidase and urease enzymes. All compounds exhibited considerable inhibitory effects on α-glucosidase and urease enzymes compared to standard inhibitors. Among them, ligand L3 displayed the highest urease inhibition, while complex C1 demonstrated the highest α-glucosidase inhibitory activity, with inhibitory activities higher than those of the standard inhibitors. Molecular docking studies were performed using AutoDock program by selecting the most effective compounds (L3 and C1). The docking results revealed strong binding affinities and significant interactions within the enzyme active sites, in agreement with the experimental findings. The overall results indicate that these isatin-derived bisthiocarbohydrazones and their Zn(II) complexes may act as promising scaffolds for the development of multifunctional enzyme inhibitors.