Akademik Veri Yönetim Sistemi
Noropsikiyatri Arsivi, cilt.32, sa.2, ss.96-101, 1995 (SCI-Expanded, Scopus)
Alzheimer's Disease (AD) is a disorder of unknown etiology with typical manifestations such as senile plaques. It has been hypothesized that the amyloid in senile plaques is formed and deposited due to degradation of Amyloid Protein Precursor (APP) by acute phase proteins which led to beta/A4 formation. If this hypothesis is proven to be true, a new era in treatment of AD may begin by clinical use of immunosuppressant drugs. Studies that have been conducted up to date were insufficient to show any difference between serum IL-1 and IL-6 levels of patients with AD and controls. IL-1 beta levels were found to be elevated in AD patients, which seem to be consistent with,this hypothesis. These studies can be criticized because of the control groups which included the patients who might have similar degenerative lesions as AD. Besides, these studies has not taken cerebrospinal fluid (CSF)/serum interleukin index into consideration to exclude peripheric pathology. To investigate 'acute phase response' hypothesis, 8 patients with AD and 12 controls without organic mental syndrome were compared in terms of IL-1 and IL-6. Serum, cerebrospinal fluid and index levels of IL-1 and IL-6 were found to be similar in both groups. However, there was positive correlation between the severity of dementia and CSF interleukin levels which seemed to support 'acute phase response' hypothesis.