LNCaP progression model of human prostate cancer: Androgen-independence and osseous metastasis
PROSTATE, cilt.44, sa.2, ss.91-103, 2000 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 44 Sayı: 2
- Basım Tarihi: 2000
- Dergi Adı: PROSTATE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.91-103
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
BACKGROUND. Clinically, the lethal phenotypes of human prostate cancer are characterized by their progression to androgen-independence and their propensity to form osseous metastases. We reported previously on the establishment of androgen-independent (AI) human prostate cancer cell lines derived from androgen-dependent (AD) LNCaP cells, with androgen independence defined as the capability of prostate cancer cells to grow in castrated hosts. One of the sublines, C4-2, was found to be AI, highly tumorigenic, and metastatic, having a proclivity for metastasis to the bone.