Hippocampal neuronal damage in rats exposed to a double hit: irradiation and hyperthermia.

Senturk G., Isler C., Kemerdere R., Ulu M. O., Umay C., Ozkaymakci A., ...Daha Fazla

Turkish neurosurgery, cilt.21, sa.4, ss.454-60, 2011 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5137/1019-5149.jtn.4012-10.1
  • Dergi Adı: Turkish neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.454-60
  • Anahtar Kelimeler: Hippocampus, Hyperthermia, Irradiation, Neuronal damage, Rat, FACTOR IMMUNOREACTIVE CELLS, TIME-DEPENDENT CHANGES, FEBRILE SEIZURES, CORTICAL DYSPLASIA, MIGRATION, EPILEPSY, MODEL, DISORDERS, CORTEX
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

AIM: In utero irradiation models induce diffuse neuronal damage. Experimental studies have shown that hyperthermia induced seizures are easily elicited and have high mortality accompanied by neuronal loss. Neuronal damage and loss are the results of cell death coupled with cortical development in altered cellular development. The aim of the study was to investigate the changes in hippocampus that was exposed to irradiation and hyperthermia.