Akademik Veri Yönetim Sistemi
Troia Medical Journal, cilt.6, sa.3, ss.83-96, 2025 (TRDizin)
Pancreatic β-cells play a crucial role in maintaining glucose homeostasis through the regulation of insulin secretion.
The electrophysiological properties of these cells, including ion channel function, electrical activity, and
secretory mechanisms, are essential for their proper physiological function. In this comprehensive review, we
provide an in-depth analysis of the electrophysiology of pancreatic β-cells. We discuss the various ion channels
involved in the generation and modulation of electrical signals, such as voltage-gated ion channels, ATP-sensitive
and delayed rectifier potassium ion channels, calcium ion channels, chloride channels and transient receptor potential
channels. Additionally, we examine the intricate interplay between intracellular calcium dynamics and insulin
release. Furthermore, we explore the physiological and pathological factors that influence the electrophysiology of
β-cells. A comprehensive understanding of the electrophysiological mechanisms governing pancreatic beta cell
function is crucial for elucidating the pathogenesis of diabetes mellitus and developing novel therapeutic strategies.