Relationship Between IL1 beta-511C > T and ILRN VNTR Polymorphisms and Keratoconus

PALAMAR ONAY M., Onay H., Ozdemir T. R., Arslan E., Egrilmez S., Ozkinay F., ...Daha Fazla

CORNEA, cilt.33, sa.2, ss.145-147, 2014 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1097/ico.0000000000000027
  • Dergi Adı: CORNEA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.145-147
  • Anahtar Kelimeler: apoptosis, genetics, interleukin, keratoconus, polymorphism, INTERLEUKIN-1-BETA, REGION, PROMOTER, GENE
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Purpose:The aim of this study was to evaluate the relationship between keratoconus (KC) and interleukin-1 (IL1 ) (-511C>T) and interleukin-1 receptor antagonist (IL1RN) variable number of tandem repeat (VNTR) polymorphisms that are potentially associated in their genetic susceptibility to KC.Methods:A total of 121 patients with KC and 121 healthy individuals were enrolled. Blood samples with ethylenediamine tetraacetic acid were obtained, and IL1 (-511C>T) (rs16944) (polymerase chain reaction-restriction fragment length polymorphism method) and IL1RN VNTR polymorphisms (rs2234663) (polymerase chain reaction and agarose gel imaging) were investigated.Results:Genotype and allele distribution for IL1 (-511C>T) and IL1RN VNTR polymorphisms among the KC and healthy groups showed no difference (for all; P > 0.05).Conclusions:Because the genotype and allele frequency of both polymorphisms are identical, it is most likely that IL1-511C>T and IL1RN VNTR polymorphisms do not play a role in the development of KC in the Turkish population.