Cytogenetic profile of adult AML patients in Turkey: a single center study with comprehensive comparison with literature

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Cirakoglu A., Kuru R. D., Yilmaz S., Deviren A., Ongoren S., Yalniz F. F., ...Daha Fazla

AFRICAN HEALTH SCIENCES, sa.3, ss.183-191, 2022 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2022
  • Doi Numarası: 10.4314/ahs.v22i3.21
  • Dergi Adı: AFRICAN HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, Index Islamicus, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.183-191
  • Anahtar Kelimeler: Acute myeloid leukemia, cytogenetics, chromosomal abnormalities, adult, ACUTE MYELOID-LEUKEMIA, WORLD-HEALTH-ORGANIZATION, MONOSOMAL KARYOTYPE, GEOGRAPHIC HETEROGENEITY, PROGNOSTIC IMPACT, AGE, CLASSIFICATION, SUBGROUPS, NEOPLASMS, REVISION
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background: Cytogenetic findings are important prognostic factors in acute myeloid leukemia. Large systematic data about chromosomal characteristics of Turkish AML patients have not been reported to date. Objectives: The karyotypic profiles of 157 adult AML patients were evaluated retrospectively and compared with other reports from different populations. Methods: Cytogenetics analyses were performed on bone marrow samples using G-banding. Patients were categorized according to their cytogenetic results into four groups with the addition of a normal karyotyped group to the favorable, intermediate and adverse groups of European Leukemia Network. Results: Cytogenetic analyses were carried out successfully in 138 patients (88%). Abnormal karyotypes were found in 79 (57.2%) patients of which 13 (9.4%) were in favorable, 37 (26.8%) in intermediate and 29 (21%) in adverse groups. t(8;21) (5%) was the most common favorable abnormality while monosomal karyotypes (15.9%) in adverse group. Conclusion: This single center study is the most comprehensive study about the cytogenetic profile of acute myeloid leukemia in Turkey with comparison of other population-based studies. While there were similarities and differences with different publications, our results did not show a marked tendency to the findings of any specific geographic region.