Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin - an antimicrobial drug

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Guncum E., Isiklan N., Anlas C., Unal N., Bulut E., Bakirel T.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.46, ss.964-973, 2018 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/21691401.2018.1476371
  • Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.964-973
  • Anahtar Kelimeler: Amoxicillin, polymeric nanocarrier, sustained release, oral drug delivery, POLY(VINYL ALCOHOL)/SODIUM ALGINATE, SOLID LIPID NANOPARTICLES, SODIUM ALGINATE, BLEND MICROSPHERES, IN-VITRO, CONTROLLED DELIVERY, ORAL DELIVERY, CHITOSAN, FORMULATION, STABILITY
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

In this study, amoxicillin (AMO)-loaded poly(vinyl alcohol)/sodium alginate (PVA/NaAlg) nanoparticles were prepared as a polymer-based controlled release system. The physicochemical properties of the obtained nanoparticles were investigated by XRD, DSC/TGA, particle size analyses and zeta potential measurements. The average particle sizes were in the range from 336.3 +/- 25.66 to 558.3 +/- 31.39 nm with negative zeta potential values from -41.86 +/- 0.55 to-47.3 +/- 2.76 mV. The influences of PVA/NaAlg ratio, span 80 concentration, exposure time to glutaraldehyde (GA) and the drug/polymer ratio on AMO release profiles were evaluated. In vitro drug release studies showed a controlled and pH dependent AMO release with an initial burst effect. XRD patterns and DSC thermograms of AMO-loaded nanoparticles revealed that the drug in the nanoparticles was in amorphous form, which was more stable than the crystalline form. The antibacterial activity of the optimal formulation was also investigated. The minimum inhibitory concentration (MIC) values of this formulation had the comparable antibacterial activity with that of pure AMO. These results indicate that the developed nanoparticles could be a promising candidate drug delivery system for AMO.