Alpha lipoic acid prevents valproic acid-induced oxidative damage in lens tissues of rats

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Oztaylan Y., Türkyılmaz İ. B., Yanardağ R.

Eurasian Biochem 2021 , Ankara, Türkiye, 24 Kasım 2021 - 26 Ocak 2022, ss.210, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.210
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Valproic acid (VPA) is an effective drug which has been widely preferred for the primary medication of epilepsy. Although this drug is used as antiepileptic drug, its deleterious effect on organs and tissues and in turn its elevator effect on oxidative stress sourced species is inevitable. Lens is one of the most affected tissues because of VPA induced oxidative stress. Alpha lipoic acid (ALA) is a potent antioxidant that inhibits the effects of free radicals. It inhibits oxidative stress by suppressing reactive oxygen species. The aim of this study was to investigate the protective effects of alpha lipoic acid against valproic acid-induced lens damage in rats. In our study, rats were divided into four groups: the control group, the ALA-treated group (50 mg / kg), the VPA-treated group (0.5 g / kg), the VPA + ALA group (at the same dose and duration).  The rats were given ALA prior to administration of VPA. ALA and VPA were administered to rats for 15 days. On day 16 rats were sacrificed and lens samples were taken. In the VPA treated lens homogenates, glutathione levels and glutathione-S-transferase activities decreased. Lipid peroxidation levels, superoxide dismutase, glutathione peroxidase, glutathione reductase, aldose reductase, sorbitol dehydrogenase activities and protein carbonyl levels increased. These values were reversed upon administration of ALA. According to the results of our study, it was concluded that alpha lipoic acid had a protective effect against valproic acid-induced lens damage.