Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.25, sa.8, ss.373-379, 1997 (Scopus)
Sixty patient who underwent arthroscopic knee surgery were divided into 4 groups in a randomized, double-blind manner. All patients received same anaesthetic protocol (2-3 mg/kg propofol+0.6 mg/kg atracurium for induction and administration of O2/N2O+0.8-1.5% isoflorane for the maintenance) and intraarticular injections of morphine (3 mg in 20 mL physiologic saline) in group M; bupivacaine (50 mg in 20 mL physiologic saline) in group B; combination of these two drugs (3 mg morphine+50 mg bupivacaine in 20 mL physiologic saline) in group M+B and only 20 mL physiologic saline in group SF was used for postoperative analgesia. A 10 cm visual analogue scale (VAS) was used for the pain assesment at 0.5., 1., 2., 3., 4., 8., 24. and 48, hours postoperatively. The VAS values of group B and M+B were significantly lower than those values of group M and SF at 0.5 and 1 h postoperatively. The VAS values of group B and M+B significantly lower than group SF 2 h after the operation but group M patients did not have any significant difference from other groups at this time. At postoperative 3rd and 4th hours group M and M+B have significantly lower values than group SF while group B values did not have any significant difference from other groups. No significant difference between 4 groups were present at 8, 24 and 48 hours. Bupivacaine was found to be more effective than morphine at the early postoperative hours, while morphine has a long efficacy. Efficacy of both drugs separately or combined was not superior to placebo after first 3 postoperative hours. For this reason combination of these two drugs seem to be the best protocol for early postoperative analgesia after arthroscopic surgery.