Warfarin pharmacogenetics in patients with heart valve replacement

Bezci, Kivanc; Cevik, Mehtap; Akdeniz, Cansu; Canbolat, Ismail; Yurdakul, Selen; SÜNBÜL, MURAT; Atas, Halil; ÇAĞATAY, Penbe; Ciftci, Cavlan; KARAALP, ATİLA; SÜSLEYİCİ, BELGİN

doi:10.1016/j.genrep.2020.100769

Warfarin pharmacogenetics in patients with heart valve replacement

Bezci K., Cevik M., Akdeniz C. S., Canbolat I. P., Yurdakul S., SÜNBÜL M., ...More

GENE REPORTS, vol.20, 2020 (ESCI, Scopus)

Publication Type: Article / Article
Volume: 20
Publication Date: 2020
Doi Number: 10.1016/j.genrep.2020.100769
Journal Name: GENE REPORTS
Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, BIOSIS, EMBASE
Istanbul University-Cerrahpasa Affiliated: Yes

Abstract

Background: Warfarin treatment is crucial to prevent thrombolytic complications after the heart valve replacement (HVR) operation. Our purpose was to investigate the prevalence of CYP2C9 *2 and *3 gene polymorphisms, which are essential in warfarin metabolism in patients with and without HVR surgery prescribed with warfarin.