PECU: A multicenter study on pediatric patients with cold-induced urticaria

Karaaslan, Betul; Soyoz, Ozgen; Celik, Figen; Akbas, Humeyra; CANITEZ, YAKUP; ERTOY KARAGÖL, HACER; Aksoydan, Beril; Oguzkaya, Yagmur; Uslu, Gizem; Erdem, Semiha; Dikici, Ummugulsum; Gungor, Hilal; Senol, Handan; Anil, Hulya; Yasar, Adem; Bulbul, Lida; Gunaydin, Nursen; Ucar, Ozge; Kaya, Mehmet; Akarcan, Sanem; Arikoglu, Tugba; Boyacioglu, Ozge; Gungor, Hatice; Ocalan, Merve; Dogru, Mahmut; Serbes, Mahir; Iskender, Nagihan; Kilic, Mehmet; Yuksek, Mutlu; Yilmaz, Ozlem; Tuncel, Tuba; Karadag, Sefika; Meric, Zeynep; Karakurt, Tuba; Aydemir, Sezin; SAYILI, UĞURCAN; Ozturk, Fadil; Sancakli, Ozlem; Bingol, Aysen; Celiksoy, Mehmet; Nursoy, Mustafa; Ozhan, Aylin; Asilsoy, Suna; Yilmaz, Ozge; Ozcan, Dilek; Simsek, Isil; Harmanci, Koray; Demir, Esen; Ozceker, Deniz; Ozdemir, Oner; Cekic, Sukru; Arga, Mustafa; Cavkaytar, Ozlem; Ercan, Nazli; Bakirtas, Arzu; Altinel, Zeynep; Can, Demet; Cokugras, Haluk; Yucel, ESRA; Kiykim, AYÇA

doi:10.1111/pai.70379

PECU: A multicenter study on pediatric patients with cold-induced urticaria

Karaaslan B. G., Soyoz O., Celik F. C., Akbas H., CANITEZ Y., ERTOY KARAGÖL H. İ., ...Daha Fazla

PEDIATRIC ALLERGY AND IMMUNOLOGY, cilt.37, sa.6, 2026 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 37 Sayı: 6
Basım Tarihi: 2026
Doi Numarası: 10.1111/pai.70379
Dergi Adı: PEDIATRIC ALLERGY AND IMMUNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest)
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background: Cold-induced urticaria (ColdU) is a rare chronic inducible urticaria that can cause systemic reactions, including cold-induced anaphylaxis (ColdA), but pediatric data are limited. The aim of this study was to evaluate the clinical characteristics, comorbidities, management approaches, risk of anaphylaxis, and long-term course of ColdU in a pediatric cohort, and to identify risk factors for ColdA, determinants of disease resolution, and predictors of persistence into adulthood. Methods: This retrospective multicenter study included 203 pediatric patients with ColdU across 30 centers in T & uuml;rkiye. Clinical characteristics and management of patients were analyzed. Logistic regression was used to identify factors associated with ColdA and disease resolution. Results: The median age at diagnosis was 14.3 years, and the median age at onset was 10 years; 56.1% of patients were female. ColdA occurred in 17.2%, with increased risk associated with male sex, autoimmune comorbidities, older age, and triggering by cold food/beverage ingestion. Most patients (82.2%) received second-generation H1-antihistamines; omalizumab achieved >90% symptom control in 12 refractory cases. Over a median 3.5-year follow-up, 30.5% achieved disease resolution (median duration: 18 months). The history of anaphylaxis and comorbid atopy significantly reduced the likelihood of remission. Some patients showed adult persistence, without clear predictors. Discussion: ColdA may occur even without classic high-risk features; pediatric ColdU management should be guided by individualized risk assessment, prioritizing clinical risk factors-such as older age, high-risk cold triggers, angioedema, and autoimmune comorbidities-over isolated diagnostic parameters. In refractory cases, omalizumab is an effective and well-tolerated option. Prior anaphylaxis and comorbid allergic disease predicted poorer remission.