Effectiveness of ultra- rapid dose titration of clozapine for treatment- resistant bipolar mania: case series

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Aksoy Poyraz C., Turan Ş., Demirel Ö. F., Usta Sağlam N. G., Yıldız N., Duran A.

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY, cilt.5, sa.4, ss.237-242, 2015 (SCI-Expanded, ESCI, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 5 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/2045125315584871
  • Dergi Adı: THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Emerging Sources Citation Index (ESCI), Scopus, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.237-242
  • Anahtar Kelimeler: clozapine, rapid titration, bipolar disorder, mania
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Treatment of severe and refractory manic episodes in hospital settings can occasionally be very difficult. In particular, severely excited patients showing aggressive, hostile, impulsive behaviours frequently require physical restraint and seclusion, high doses of antipsychotics and benzodiazepines, and sometimes, electroconvulsive therapy. Hospital stay is generally prolonged and such patients cause great emotional distress for other patients in the ward and clinical staff involved in their care.