Recent Researches and Reviews in Mathematics and Natural Science, Prof.Dr.Rıdvan KARAPINAR, Editör, Livre De Lyon, Lyon, ss.39-52, 2022
Multicomponent reactions (MCRs), which enable multistep synthesis
to be conducted in a single procedural step to produce novel and
highly functionalized organic molecules and biologically active
heterocyclic compounds from straightforward and easily accessible starting
materials are currently becoming valuable synthetic strategies in modern
organic and medicinal chemistry. These reactions have the potential to lead to
efficient, secure, cost-effective, high-yield, environmentally friendly processes
and to decrease the production of chemical waste (Liu et al., 2015). One of the
most significant synthetic processes for forming carbon-carbon bonds is the
Mannich reaction. In the essential C-C bond-forming stages of the synthesis of
several types of natural and bioactive compounds, the Mannich condensation
process has been extensively utilized (Madar et al., 2018; Yaşa and Demir,
2019a; Olyaei et al., 2020).