Flow injection amperometric determination of L-cysteine at a Bis-(neocuproine)copper (II) complex modified screen-printed carbon electrode

Erşan T., DİLGİN Y., APAK M. R.

Journal of Solid State Electrochemistry, 2026 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1007/s10008-026-06710-0
  • Dergi Adı: Journal of Solid State Electrochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Chemical Abstracts Core, Compendex, INSPEC, Academic Search Ultimate (EBSCO), Engineering Source (EBSCO), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
  • Anahtar Kelimeler: Bis-(neocuproine)copper(II) complex, Flow injection analysis, L-cysteine, Modified electrode, Screen-printed carbon electrode
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

This study describes the electrocatalytic oxidation of L-cysteine (L-Cys) and its flow injection amperometric quantification using a bis-(neocuproine)copper(II) ([Cu(Nc)2]2+) complex/Nafion/multiwalled carbon nanotube composite modified screen-printed carbon electrode ([Cu(Nc)2]2+/Nf@MWCNT/SPCE). The negatively charged (sulfonate-bearing) polymeric material (Nf) on the electrode surface interacts electrostatically with the positively charged cupric complex, providing an effective approach for the attachment of the redox mediator to the SPCE surface. Cyclic voltammetric results indicate that L-Cys undergoes electrocatalytic oxidation on the modified electrode at +600 mV, which is approximately 200 mV more negative than on the unmodified electrode. A broad linear range was achieved from 1.0 to 1500 µmol L-1 L-Cys, with a detection limit (LOD) of 0.34 µmol L-1, as determined by the calibration curve obtained in the FI amperometric studies on the [Cu(Nc)2]2+/Nf@MWCNT/SPCE under optimized conditions. The proposed modified electrode, exhibiting high sensitivity and selectivity toward L-Cys, was successfully applied to three different milk samples and yielded satisfactory recovery results.