Oxidative stress-mediated (sex-specific) loss of protection against type-2 diabetes by macrophage migration inhibitory factor (MIF)-173G/C polymorphism

Coban, Neslihan; Onat, Altan; Yildirim, Ozlem; Can, GÜNAY; Erginel-Unaltuna, Nihan

doi:10.1016/j.cca.2014.07.037

Oxidative stress-mediated (sex-specific) loss of protection against type-2 diabetes by macrophage migration inhibitory factor (MIF)-173G/C polymorphism

Coban N., Onat A., Yildirim O., Can G. , Erginel-Unaltuna N.

CLINICA CHIMICA ACTA, vol.438, pp.1-6, 2015 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 438
Publication Date: 2015
Doi Number: 10.1016/j.cca.2014.07.037
Title of Journal : CLINICA CHIMICA ACTA
Page Numbers: pp.1-6
Keywords: MIF gene, Polymorphism, apoB, Glucose, Diabetes mellitus, AUGSBURG CASE-COHORT, FACTOR MIF, METABOLIC SYNDROME, ABDOMINAL OBESITY, CORONARY-DISEASE, RISK-FACTORS, FOLLOW-UP, GENE, ASSOCIATION, VARIANTS

Abstract

Background: The archetypical yet atypical cytokine macrophage migration inhibitory factor (MIF) fulfills pleiotropic immune functions in inflammatory diseases. Evidence emerging from both expression and functional studies implicates MIF in various aspects of cardiovascular diseases. We aimed to determine the covariates of MIF -173G/C polymorphism and its influence on type-2 diabetes risk in a sample representative of middle-aged Turks.