Impact of laterality on seizure duration in mesial temporal lobe epilepsy with hippocampal sclerosis
Epilepsy and Behavior Reports, cilt.34, 2026 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 34
- Basım Tarihi: 2026
- Doi Numarası: 10.1016/j.ebr.2026.100857
- Dergi Adı: Epilepsy and Behavior Reports
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, Directory of Open Access Journals
- Anahtar Kelimeler: Hippocampal sclerosis, Laterality, Seizure duration, Status epilepticus
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Objective This study aims to evaluate differences in seizure durations in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) based on laterality, along with other related findings. Methods This retrospective trial (2009–2023) at Istanbul University-Cerrahpasa’s VEM Unit reviewed patients diagnosed with MTLE-HS via MRI and/or postoperative histopathology. Demographic data, epilepsy duration, and MTLE laterality were recorded. Seizure durations (excluding bilateral tonic-clonic periods) were analyzed, including the shortest, longest, and average seizure durations per admission. The occurrence of prolonged seizures without progression to bilateral tonic-clonic seizures (PS) was also documented. Results The study included 82 participants, with 58.5% (n = 48) left-sided and 41.5% (n = 34) right-sided MTLE-HS cases. The shortest recorded seizure duration showed no significant difference between sides (p ' 0.05), but the longest seizure was significantly longer in right-sided MTLE-HS (p = 0.014). The mean seizure duration per patient was also significantly longer in the right-sided group (p = 0.035). PS occurred in 17.1% (n = 14) of participants, with a significantly higher incidence in right-sided MTLE-HS (p = 0.002). Significance This study suggests that seizure durations may be longer in right-sided (non-dominant) MTLE-HS compared to left-sided (dominant) cases, contributing new insights into the lateralization of MTLE-HS.