Impact of laterality on seizure duration in mesial temporal lobe epilepsy with hippocampal sclerosis

TÜRK B. G., Abanoz Y., Abanoz Y., Arik B. E., Ukus B., Yildirim E. N., ...Daha Fazla

Epilepsy and Behavior Reports, cilt.34, 2026 (ESCI, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.ebr.2026.100857
  • Dergi Adı: Epilepsy and Behavior Reports
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, EMBASE, Directory of Open Access Journals
  • Anahtar Kelimeler: Hippocampal sclerosis, Laterality, Seizure duration, Status epilepticus
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective This study aims to evaluate differences in seizure durations in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) based on laterality, along with other related findings. Methods This retrospective trial (2009–2023) at Istanbul University-Cerrahpasa’s VEM Unit reviewed patients diagnosed with MTLE-HS via MRI and/or postoperative histopathology. Demographic data, epilepsy duration, and MTLE laterality were recorded. Seizure durations (excluding bilateral tonic-clonic periods) were analyzed, including the shortest, longest, and average seizure durations per admission. The occurrence of prolonged seizures without progression to bilateral tonic-clonic seizures (PS) was also documented. Results The study included 82 participants, with 58.5% (n = 48) left-sided and 41.5% (n = 34) right-sided MTLE-HS cases. The shortest recorded seizure duration showed no significant difference between sides (p ' 0.05), but the longest seizure was significantly longer in right-sided MTLE-HS (p = 0.014). The mean seizure duration per patient was also significantly longer in the right-sided group (p = 0.035). PS occurred in 17.1% (n = 14) of participants, with a significantly higher incidence in right-sided MTLE-HS (p = 0.002). Significance This study suggests that seizure durations may be longer in right-sided (non-dominant) MTLE-HS compared to left-sided (dominant) cases, contributing new insights into the lateralization of MTLE-HS.