Endometrial mixed mullerian tumor with heterologous elements following tamoxifen therapy for breast cancer: a case report and literature review

Kaleli S., Calay Z., Altinok T., Kosebay D.

EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.101, sa.2, ss.204-208, 2002 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 101 Sayı: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0301-2115(01)00529-2
  • Dergi Adı: EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.204-208
  • Anahtar Kelimeler: tamoxifen, complication, endometrial cancer, uterine sarcoma, mixed mullerian, tumor, breast cancer, MMT, UTERINE CORPUS, RAT UTERUS, ADENOSARCOMA, CARCINOMA, CARCINOSARCOMA, ACTIVATION, SARCOMAS, PATIENT, RISK
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Case: A 67-year-old multiparous woman received 20 mg tamoxifen daily for four years after surgical treatment of breast cancer. She presented with vaginal bleeding. Uterine curettage revealed a uterine MMT with heterologous elements. She was treated surgically with adjuvant radiotherapy. Tumor cells were found to be estrogen receptor negative and progesterone receptor positive. Uterine MMT may be linked to long term use of tamoxifen. A mechanism in developing MMT other than estrogen receptor pathway may be possible. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.