Research Information System
Experimed, vol.11, no.1, pp.27-32, 2021 (TRDizin)
Objective: Diabetes mellitus is a metabolic disease of global importance.
It affects many people by reducing their quality of life
and even causing death. Therefore, research on diabetes mellitus
maintains its popularity and continues to develop. Chard (Beta
vulgaris L. var. cicla) is commonly used in diets and is known to
have alternative hypoglycemic effects in diabetic individuals. This
study investigated the protective effects of chard on glycoproteins
(hexose, hexosamine, fucose, and sialic acid) and the advanced oxidation
protein product levels in diabetic rats’ livers.
Materials and Methods: For this experiment, male Sprague–Dawley
rats were separated into three groups: the control; Streptozotocin
(STZ)-induced diabetic rats; and STZ-induced diabetic + chard
extract. Fourteen days after diabetes induction, chard extract
(2 g/kg/day, gavage) was administered for 45 days. On day 60, liver
samples were collected, and 10% (w/v) homogenate was prepared
for the analysis of glycoprotein components and advanced oxidation
protein products.
Results: Levels of glycoprotein parameters that include hexose,
hexosamine, fucose, and sialic acid, as well as advanced oxidation
protein product levels increased in the diabetic group. Chard extract
administration curatively reverted the altered biochemical
parameters.
Conclusion: From the results obtained, it can be suggested that
chard extract has a protective effect on the diabetic livers of rats.