Protective effect of nebivolol on gentamicin-induced nephrotoxicity in rats.

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Dursun M., Sahin S., Besiroglu H., Otunctemur A., Ozbek E., Cakir S. S., ...Daha Fazla

Bratislavske lekarske listy, cilt.119, sa.11, ss.718-725, 2018 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 119 Sayı: 11
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4149/bll_2018_128
  • Dergi Adı: Bratislavske lekarske listy
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.718-725
  • Anahtar Kelimeler: nebivolol, rat, gentamicin, oxidative stress, nephrotoxicity, NITRIC-OXIDE RELEASE, ANGIOTENSIN-II, TUBULOINTERSTITIAL NEPHRITIS, ENDOTHELIAL DYSFUNCTION, ADHESION MOLECULE-1, INDUCED APOPTOSIS, RENAL-FAILURE, FREE-RADICALS, SUPEROXIDE, MECHANISMS
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

OBJECTIVE: Nephrotoxicity is a major complication of gentamicin (GEN), which is widely used in the treatment of severe Gram-negative infections. As we know, treatment with nebivolol has been shown to decrease renal fibrosis and glomerular injury as well as improve endothelial dysfunction. Therefore, we evaluated the potential protective effect of nebivolol (NBV) against GEN-induced nephrotoxicity in rats.