Association between the CCR5 32-bp deletion allele and obsessive-compulsive disorder (OCD)

Özdemircan A., Küçükali C. İ., Daşdemir S., Çinçin Z. B., Özkök E., Çakmakoğlu B.

4th International Congress of Molecular Medicine, İstanbul, Türkiye, 27 - 30 Haziran 2011, cilt.1, sa.1, ss.94, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Cilt numarası: 1
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.94
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background: Obsessive-compulsive disorder (OCD) affects children and adults. As in most psychiatric disorders, genetic and environmental factors play an important role in the development of OCD. Chemokines and their receptors are involved in the regulation of a variety of normal functions in the brain, including those of neurodevelopment, intercellular communication and neuronal survival. The chemokine receptor 5 (CCR5) binds a number of chemokines and may play a role in the development of OCD. We prospectively investigated whether CCR5 delta 32 Insertion/deletion polymorphism account for an increased risk of obsessive-compulsive disorder.

Methods: The present analyses are based on 48 case subjects with obsessivecompulsive disorder and 100 non-case subjects. Genotyping of the CCR5 32-nucleotide deletion polymorphism was accomplished by enzymatic amplification of genomic DNA and agarose gel electrophoresis of amplified fragments.

Results: CCR5-delta32 genotype distribution of cases differed significantly from that of controls (p=0.043). Frequencies of CCR5 delta 32 insertion/deletion genotypes were 81% wt/wt, 7% deletion/deletion, 12% wt/deletion in the control group and 95.8% wt/wt, 0% deletion/deletion and 2% wt/deletion in the patient group. Conclusion: It is likely that CCR5 delta 32 insertion/deletion variants affect susceptibility to OCD.