Akademik Veri Yönetim Sistemi
5th International Eurasian Conference on Biological and Chemical Sciences (EurasianBioChem 2022), Ankara, Türkiye, 23 - 25 Kasım 2022, ss.1661, (Özet Bildiri)
Cirrhosis is a globally important cause of morbidity and mortality, affecting not only the liver but also many organs such
as the brain. The aim of the present study was to evaluate the possible protective effects of bitter melon (BM), chard and
parsley extracts on brain injury in rats with bile duct ligation (BDL) induced biliary cirrhosis. In this study, female Sprague
Dawley rats were divided into five groups: Control group (C): Sham-operated, 0.9% physiological saline was given; BDL
group: The common bile duct was separated and ligated by double ligatures with suture silk; BDL+BM group: BM extract
(50 mg/kg) administered BDL animals; BDL+chard group: Chard extract (2 g/kg) administered BDL animals;
BDL+parsley: Parsley extract (2 g/kg) administered BDL animals for 28 days. At the end of the study, all the animals
were sacrificed and brain tissues were taken and homogenized in physiological saline to make 10% (w/v) homogenates.
Acetylcholinesterase (AChE), xanthine oxidase (XO), lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase
(G6PDH) and carbonic anhydrase (CA) activities were determined in brain homogenates. According to the results, AChE,
XO and LDH activities were found to increase, while G6PDH and CA activities were decreased in the BDL group as
compared to the control group. Administration of the plant extracts reversed these effects probably by their unique
antioxidant property. In this study, it was observed that the plant extracts prevented the damage caused BDL induced
biliary cirrhosis in rats’ brains.