Functional and histopathological investigation of the remote organ injury in cochlea after ischemia and reperfusion caused by aortic occlusion
Journal of International Advanced Otology, cilt.8, sa.1, ss.9-15, 2012 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 1
- Basım Tarihi: 2012
- Dergi Adı: Journal of International Advanced Otology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.9-15
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Objective: To assess the toxic remote organ damage in the cochlea due to ischemia-reperfusion injury following descending aorta surgery, and to investigate the protective effect of iloprost and ascorbic acid. Materials and Methods: Twenty-one New Zealand rabbits were divided in to 3 groups. In group 1 and 2, a remote injury was created in the cochlea after ischemia-reperfusion injury in spinal cord, renal and lower extremities caused by clamping the descending aorta. In group 1, no additional medications were given. In group 2, iloprost and ascorbic acid were infused 30 minutes before and two hours after the surgical procedure. A sham operation was performed in group 3. The cochlear function was tested using Otoacoustic Emission (OAE) testing before and after the operation. In addition, the cochlea was examined using electron microscopy. Results: OAE amplitudes decreased postoperatively in group 1 (p<0.05). In group 2, pre- and postoperative OAE results were not significantly different (p>0.05). In group 3, a postoperative decrease was encountered at only 4 kHz after the operation (p<0.05). The morphological changes were more prominent in group 1 when compared to group 2. Conclusion: Cochlear remote organ damage can occur after ischemia-reperfusion injury in spinal cord, renal and extremities. Iloprost and ascorbic acid has a protective effect against this injury. © 2005 The Mediterranean Society of Otology and Audiology.