Akademik Veri Yönetim Sistemi
Annals of Medical Research, cilt.27, sa.7, ss.1961-1965, 2020 (TRDizin)
Aim: Insulin degludec/aspart (IDegAsp) co-formulation therapy is a novel drug in Turkey and the aim of this study was toretrospectively evaluate the effects of IDegAsp therapy on glycemic control and hypoglycemia in a single tertiary center in Turkey.Material and Methods: The medical records of patients with type 2 diabetes mellitus, who were evaluated at diabetes clinic ofCerrahpaşa Medical Faculty between January and April 2018 and had started to use IDegAsp, were investigated. The demographiccharacteristics of the patients, anti-diabetic medications they were currently using, causes of treatment change, the IDegAsp doses,fasting blood glucose (FBG), HbA1c and hypoglycemic episodes at treatment onset, the third and sixth months of therapy wereevaluated.Results: Sixty-six patients (F/M:34/32; mean age:57.8±11,6years) were evaluated. Uncontrolled hyperglycemia (80.3%) and frequenthypoglycemic attacks (19,7%) were the causes of treatment change. IDegAsp was started as a single dose in 53% and doubledose in 47% of patients. Sixty-two patients (93.9%) were using insulin and the number of injections were signifiantly reduced withIDegAsp (p<0.001). There was no statistically signifiant difference in terms of insulin doses in sixth months of treatment (p=0.054),whereas FBG (p<0.001), HbA1c (p<0.001) levels and hypoglycemic attacks (p<0.001) were reduced and the improvement in glycemiccontrol occured particularly in the fist 3 months of therapy.Conclusion: Glycemic control and hypoglycemic episodes were improved and the number of daily injections decreased with 6-monthsof IDegAsp treatment. IDegAsp, which is a novel drug for our country, may increase the treatment compliance of the patients andthus facilitate reaching the glycemic targets.