Active vitamin D is cardioprotective in experimental uraemia but not in children with CKD Stages 3-5.

Schön, A; Leifheit-Nestler, M; Deppe, J; Fischer, DC; Bayazit, AK; Obrycki, L; Canpolat, NUR; Bulut, IK; Azukaitis, K; Yilmaz, A; Mir, S; Yalcinkaya, F; Soylemezoglu, O; Melk, A; Stangl, GI; Behnisch, R; Shroff, R; Bacchetta, J; Querfeld, U; Schaefer, F; Haffner, D; 4C and, Study

doi:10.1093/ndt/gfaa227

Active vitamin D is cardioprotective in experimental uraemia but not in children with CKD Stages 3-5.

Schön A., Leifheit-Nestler M., Deppe J., Fischer D., Bayazit A., Obrycki L., ...Daha Fazla

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, cilt.36, ss.442-451, 2021 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 36
Basım Tarihi: 2021
Doi Numarası: 10.1093/ndt/gfaa227
Dergi Adı: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
Sayfa Sayıları: ss.442-451
Anahtar Kelimeler: chronic kidney disease, fibroblast growth factor 23, left ventricular hypertrophy, renin-angiotensin system, vitamin D, LEFT-VENTRICULAR HYPERTROPHY, CHRONIC KIDNEY-DISEASE, GROWTH-FACTOR 23, CARDIAC-HYPERTROPHY, D THERAPY, KLOTHO, PARICALCITOL, CALCIUM, BONE, FIBROBLAST-GROWTH-FACTOR-23
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background. Uraemic cardiac remodelling is associated with vitamin D and Klotho deficiency, elevated fibroblast growth factor 23 (FGF23) and activation of the renin-angiotensin system (RAS). The cardioprotective properties of active vitamin D analogues in this setting are unclear.