SYNTHESIS OF 2-FLUOROBENZOYL THIOUREA DERIVATIVES
İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi, vol.22, no.44, pp.417-424, 2023 (TRDizin)
- Publication Type: Article / Article
- Volume: 22 Issue: 44
- Publication Date: 2023
- Doi Number: 10.55071/ticaretfbd.1364818
- Journal Name: İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi
- Journal Indexes: TR DİZİN (ULAKBİM)
- Page Numbers: pp.417-424
- Istanbul University-Cerrahpasa Affiliated: Yes
Abstract
Fluorine-containing compounds play a significant role in drug development because fluorine atom has unique chemical properties due to its high electronegativity which significantly influences the properties important for drug design. In the present study, 2-fluorobenzoyl thiourea derivatives were synthesized by the reaction of 2-fluorobenzoyl isothiocyanate, which was obtained by the reaction of 2-fluorobenzoyl chloride with ammonium thiocyanate, with appropriate aniline derivatives. The structures of the benzoyl thioureas were confirmed by IR, 1H and 13C NMR spectroscopy.