SYNTHESIS OF 2-FLUOROBENZOYL THIOUREA DERIVATIVES
İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi, cilt.22, sa.44, ss.417-424, 2023 (TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 44
- Basım Tarihi: 2023
- Doi Numarası: 10.55071/ticaretfbd.1364818
- Dergi Adı: İstanbul Ticaret Üniversitesi Fen Bilimleri Dergisi
- Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.417-424
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
Fluorine-containing compounds play a significant role in drug development because fluorine atom has unique chemical properties due to its high electronegativity which significantly influences the properties important for drug design. In the present study, 2-fluorobenzoyl thiourea derivatives were synthesized by the reaction of 2-fluorobenzoyl isothiocyanate, which was obtained by the reaction of 2-fluorobenzoyl chloride with ammonium thiocyanate, with appropriate aniline derivatives. The structures of the benzoyl thioureas were confirmed by IR, 1H and 13C NMR spectroscopy.