HSP-10 in ovarian cancer: Expression and suppression of T-cell signaling

Akyol S., Gercel-Taylor C., Reynolds L. C., Taylor D. D.

GYNECOLOGIC ONCOLOGY, cilt.101, sa.3, ss.481-486, 2006 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 101 Sayı: 3
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/j.ygyno.2005.11.014
  • Dergi Adı: GYNECOLOGIC ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.481-486
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective. Suppressed T-cell activation is a hallmark of advanced ovarian cancer. Studies in pregnancy have demonstrated similar T-cell dysfunction mediated, at least in part, by HSP10, identified as "early pregnancy factor." This pilot study addresses the presence of HSP10 in the circulation of ovarian cancer patients and assesses its role in suppressing CD3-zeta.