Akademik Veri Yönetim Sistemi
Klinik Gelisim, cilt.9, sa.1, ss.4013-4018, 1996 (Scopus)
To determine the effects of testosterone replacement on serum lipids, body composition and osteoblastic activity in young men with hypogonadism, we measured serum lipids, and total body water, fat-free mass and fat mass by bioelectrical impedance, and serum osteocalcin level in 15 men (aged 17-25 years) with hypogonadism before and at the 8th month of the intramuscular testosterone replacement therapy. The findings were compared with those of a control group consisting of 15 healthy men matched for age and body mass index. The serum high density lipoprotein cholesterol (HDL-C) level and fat mass were significantly higher whereas fat-free mass was lower in the hypogonadism group than that in the control group. At the 8th month of the replacement therapy which had established a normal serum testosterone level, body weight, body water, fat-free mass and serum osteocalcin level increased significantly, whereas fat mass and serum HDL-C level decreased significantly. These findings show that the intramuscular testosterone replacement therapy in hypogonadal men normalizes body composition by decreasing fat mass and increasing fat-free mass, and increases osteoblastic activity, and decreases serum HDL-C level.