Drug Design: Fish Ear Crystal Otolith - Teak Tree Extract Cahoots for Pharmacologia Industry
International Conferences on Science and Technology Natural Science and Technology, Budapest, Macaristan, 28 - 30 Mayıs 2025, ss.1, (Özet Bildiri)
- Yayın Türü: Bildiri / Özet Bildiri
- Basıldığı Şehir: Budapest
- Basıldığı Ülke: Macaristan
- Sayfa Sayıları: ss.1
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
Fish ear crystal (this term is often called
"otoliths") and teak tree extract are very interesting and
potentially valuable components in the pharmacology industry. These two
substances can be associated with scientific research and various
pharmaceutical applications regarding their effects on human health, which are
found in nature. Otoliths are small calcium carbonate crystals found in the
ears of fish, which provide balance. Otoliths, also known as ear crystals, are
found in all fish except rays, jawless fish and sharks. Otoliths are white in
color and have a calcium carbonate (CaCO3) structure. Otoliths,
which are not attached to the skull, float in the soft, transparent inner ear
canal under the brain. Otolith is also a detection organelle in determining the
age of the fish. There are 3 pairs of otoliths in fish: Sacitta, Lapilli,
Asterisk. This component has not yet been widely studied pharmacologically.
However, this precious stone should be investigated immediately. Otoliths
contain large amounts of calcium and magnesium. These minerals are important
for bone health and can be evaluated as a potential treatment especially for
bone diseases (osteoporosis etc.) and musculoskeletal disorders. It can be
transformed into a new source that can be used in the treatment of osteoporosis.
It is also thought that otoliths, especially those extracted from the skull of
the kingfisher (Sciaena umbra), can
break down kidney stones. However, this issue should be further investigated
and studied. It can be included in products such as calcium and magnesium
supplements. Some minerals and elements contained in otoliths are effective
against microorganisms. Studies show that such minerals can reduce inflammation
and have positive effects on the immune system. It can play a supporting role
in the treatment of conditions such as skin infections and wound healing
processes, and joint disorders. The microscopic structure of otolith is
suitable for nanotechnological applications. The nanometric design of mineral
particles makes their biological effects more apparent. Studies can be
conducted on drug delivery systems and nanoparticle therapy. Teak tree,
especially the "Tectona grandis"
species, is known for its versatile use and high durability. Teak tree extract
and compounds obtained from this tree are used in antimicrobial pharmacology
against skin infections and some internal organ infections. Teak tree extract
provides anti-inflammatory and analgesic (pain relieving) effects, especially
in conditions such as joint pain, muscle tension and arthritis, and can be
included in cream formulations. Teak tree extract reduces cell damage, delays
aging, prevents acne, eczema, skin infections, inflammatory skin diseases and
cardiovascular diseases thanks to some antioxidant compounds it contains. In
addition, research on cell renewal and tissue repair is ongoing. In short, with
extraction, standardization, combinations with natural compounds,
nanotechnology and advanced formulation studies, the effective combination of
teak tree extract and otolith is recommended as a potential drug active
ingredient in the pharmacological industry.