Akademik Veri Yönetim Sistemi
5th International Eurasian Conference on Science, Engineering and Technology (EurasianSciEnTech 2024), Ankara, Türkiye, 26 - 28 Haziran 2024, ss.1527, (Özet Bildiri)
Valproic acid or its salt (sodium valproate, SVP) is the standard of care for epilepsy management that primarily affects bipolar disorder, mania, and migraine. Despite its therapeutic usage of SVP, it has been reported to bring about unwanted/side effects in various tissues. Moringa oleifera Lam. (MO) is grown in many countries and is used as a medicinal plant owning to its diverse biofunctional and phytochemical properties as well as rich nutritional components. MO has been reported to have antioxidant, anti-obesity, glucose-lowering, antihypertensive, and anti-inflammatory effects. The main goal of the present work was to evaluate possible protective role of hydroalcoholic extract of MO leaves against SVP-induced oxidative brain injury in rats. Female Sprague-Dawley rats were randomly assigned into four groups as follows: Control animals (Group I) orally given similar dose of physiologic saline; Group II (MO) was administered to oral route only 70% ethanol extract of MO leaves for 15 days (300 mg/kg/day). Group III (SVP) was given only SVP for 15 days (500 mg/kg/day) orally. Group IV (SVP + MO) was given similar dose of SVP + MO extract for 15 days. At the end of the experiment (on the 16th day), all the animals were fasted overnight, sacrificed under anesthesia. Brain tissues were dissected out, thereafter 10% homogenates were prepared. According to our findings, glycoprotein (fucose, hexosamine, and mucin) contents and hydroxyproline levels were found to be a remarkable elevation in SVP given groups. Conversely, treatment with MO extract to the SVP group reversed these alterations in the parameters evaluated in this study. As a consequence, MO may ameliorate SVP-mediated oxidative brain injury in rats due to its diverse biofunctional properties.