HLA type determination in patients diagnosed with mycosis fungoides and sézary syndrome Mikozis fungoides ve sézary sendromu tanısı alan hastalarda HLA tip tayini

Başaran A. R., Engın B., Oba M. Ç., YILMAZ E. M., Kutlubay Z., SERDAROĞLU Ü. S.

Turkiye Klinikleri Journal of Medical Sciences, cilt.39, sa.1, ss.42-47, 2019 (Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5336/medsci.2018-62421
  • Dergi Adı: Turkiye Klinikleri Journal of Medical Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.42-47
  • Anahtar Kelimeler: Disease susceptibility, HLA antigens, Mycosis fungoides
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Objective: Mycosis fungoides (MF) and Sézary syndrome (SS) represent the most frequently encountered subtypes of primary cutaneous T-cell lymphoma. The human leukocyte antigen (HLA) system was shown to be involved in susceptibility to MF/SS in various studies involving populations of different genetic backgrounds. We aimed to determine the possible association of HLA system with MF/SS in Turkish cases. Material and Methods: A total of 30 MF/SS cases underwent genotyping for HLA-A, HLA-B and HLA-DR loci. Samples from 30 healthy subjects were obtained as controls. Results: Statistically significant associations were found between MF and HLA-A31, HLA-B51 and HLA-DR3 alleles. A significantly higher frequency of HLA-B35 and HLADR4 was noted in healthy controls as compared with the patients. Conclusion: This study suggests that HLA genotypes are involved in susceptibility to MF. HLA-A31, HLA-B51 and HLA-DR3 alleles were considered as markers to disease susceptibility whereas HLA-B35 and HLA-DR4 alleles may be protective against neoplastic transformation.