Serum and cerebrospinal fluid concentrations of E-selectin in patients with aneurysmal subarachnoid hemorrhage

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TANRIVERDİ T., SANUS G. Z., ULU M. O., TURECİ E., Uzun H., Aydin S., ...Daha Fazla

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, cilt.38, sa.11, ss.1703-1710, 2005 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 11
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1590/s0100-879x2005001100020
  • Dergi Adı: BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1703-1710
  • Anahtar Kelimeler: adhesion molecules, E-selectin, selectin, subarachnoid hemorrhage, vasospasm, INTERCELLULAR-ADHESION MOLECULE-1, ENDOTHELIAL-CELL-INTERACTIONS, MONOCLONAL-ANTIBODIES, ICAM-1, MECHANISMS, EXPRESSION, IMMUNOGLOBULIN, ACTIVATION, VASOSPASM
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

The goal of the present study was to determine concentrations of E-selectin in both cerebrospinal fluid (CSF) and serum of patients with aneurysmal subarachnoid hemorrhage (SAH) and to evaluate the correlation between the clinical parameters and E-selectin levels. Both CSF and serum samples obtained from 12 patients with aneurysmal SAH and 8 patients with hydrocephalus (control group) without any other known central nervous system disease were assayed for E-selectin by quantitative enzyme-linked immunosorbent assay and the results were compared between the two groups. Mean levels of soluble forms of E-selectin within the first 3 days and on the 5th and 7th days of SAH were 4.0 +/- 7.9, 2.8 +/- 5.2, and 3.1 +/- 4.9 ng/ml in the patient's CSF, and 33.7 +/- 9.2, 35.1 +/- 7.0, and 35.2 +/- 8.7 ng/ml in serum, respectively. In contrast, mean E-selectin levels were 0.1 +/- 0.2 ng/ml in CSF and 8.7 +/- 5.0 ng/ml in serum of control patients. The difference between groups was statistically significant regarding both CSF and serum E-selectin levels (P < 0.05). Thus, we have demonstrated a marked increase of E-selectin concentration in both CSF and serum of patients with aneurysmal SAH compared with control and suggest that blocking the interaction between E-selectin and vascular endothelium may have a beneficial effect on vasospasms.