The Outcomes of Chronic Myeloid Leukemia Patients With Molecular Warning Responses During Imatinib Treatment According to the European LeukemiaNet 2013 Recommendations
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, cilt.19, sa.7, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 7
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.clml.2019.03.028
- Dergi Adı: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Chronic myeloid leukemia, European LeukemiaNet (ELN), Imatinib, Tyrosine kinase inhibitor, Warning, MANAGEMENT
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
We retrospectively evaluated 73 chronic myeloid leukemia patients receiving first-line imatinib and compared patients with molecular warning response (WR) with patients with optimal response (OR) and failure regarding short- and long-term outcomes. The cumulative major molecular response (MMR) rates in patients with OR were significantly higher at any timepoint than those achieved by the WR group. Patients with WR at 3 months had significantly inferior failure-free survival (FFS) than optimal responders, but overall survival (OS) was similar. At 6 and 12 months, the WR and OR groups had similar FFS and OS. Twenty of 23 patients with WR at 12 months achieved MMR with imatinib.