Akademik Veri Yönetim Sistemi
Journal of Rheumatology and Medical Rehabilitation, cilt.17, sa.4, ss.243-250, 2006 (Scopus)
Introduction: Vitamin D receptor gene has been implicated as a factor affecting bone mass. Clinical and epidemiological studies have suggested a correlation between vitamin D deficiency and high blood pressure. In this study, the relationship between Vitamin D receptor (VDR) intragenic polymorphisms Fok-I, Bsm-I and Apa-I and bone mineral density (BMD) and bone turnover markers were investigated. Methods: Fifty six hypertensive postmenopausal women, on average 47.8±8.6 years of age were included in the study. The VDR genotypes were detected by PCR-RFLP method. BMD at the spine and at the hip were measured by dual-energy X-ray absorptiometry. Serum concentrations of alkaline phoshatase, parathyroid hormone, calcium, phosphate and urinary deoxypyridinoline, daily urinary calcium excretion levels were measured to evaluate the bone metabolism. Patients were distributed as FF (n=27) and non-FF (Ff and ff) groups (n=29) for Fok-I polymorphism. Results: Subjects with non-FF group had significantly lower BMD at the spine than those with the FF group (p= 0.038). Osteoporosis and osteopenia at the lumbar spine were found as 22.7% (n = 6) in the FF group and 62.0% (n = 18) in the non-FF group. There were no relationship between Bsm-I and Apa-I VDR polymorphisms and BMD at any skeletal site. In Fok-I, Bsm-I and Apa-I restriction sites the biochemical markers of bone remodeling did not differ by genotype. Conclusion: Fok-I genotype of the vitamin D receptor gene may be related to bone mass in hypertensive postmenopausal woman. It is not known how VDR polymorphism could influence the blood pressure, but calcium and vitamin D supplementation as a part of treatment of postmenopausal osteoporosis in hypertensive women could be also effective on reduction of blood pressure.