DPP4 inhibitor induces beta cell regeneration and DDR-1 protein expression as an endocrine progenitor cell marker in neonatal STZ-diabetic rats

Argun-Kurum G., Kaya-Dagistanli F., Ozturk M.

PHARMACOLOGICAL REPORTS, cilt.71, sa.4, ss.721-731, 2019 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.pharep.2019.03.008
  • Dergi Adı: PHARMACOLOGICAL REPORTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.721-731
  • Anahtar Kelimeler: DDR-1, beta cell regeneration, DPP4 inhibitor, Apoptosis, Neonatal-STZ diabetes, GLUCAGON-LIKE PEPTIDE-1, PANCREATIC TRANSCRIPTION FACTOR, RECEPTOR TYROSINE KINASES, FACTOR PDX-1, IN-VIVO, STREPTOZOTOCIN, VILDAGLIPTIN, ACTIVATION, MASS, EXENDIN-4
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background: We aim to investigate the effects of dipeptidyl-peptidase-4 inhibitor (Vildagliptin-VG) on DDR-1 as a marker for endocrine progenitor cells, beta-cell regeneration, and apoptosis in neonatal streptozotocin (n2-STZ) diabetics.