Akademik Veri Yönetim Sistemi
JOURNAL OF CARDIOTHORACIC SURGERY, cilt.21, sa.1, 2026 (SCI-Expanded, Scopus)
Background Lung adenocarcinoma is the most common subtype of non-small cell lung cancer (NSCLC) and has shown increasing incidence worldwide. Although early-stage lung adenocarcinoma generally has a better prognosis, recurrence occurs in 30-50% of cases. Surgical resection remains the gold standard treatment for early-stage disease. Identifying prognostic factors is essential for guiding postoperative follow-up and determining the need for adjuvant therapy. Materials and methods We retrospectively evaluated 1,057 patients who underwent surgery for early-stage lung adenocarcinoma between 2007 and 2020 at two thoracic surgery centers. Descriptive statistics, including means and standard deviations, were calculated for continuous variables. Survival analysis was performed using Kaplan-Meier estimates, and prognostic factors were assessed through Cox proportional hazards regression. Results The mean age was 61.2 +/- 9.0 years (range: 23-87), with 284 females (26.9%) and 773 males (73.1%). Female patients demonstrated significantly better survival (p < 0.001). Poor survival outcomes were associated with pathological N1 involvement, as well as lymphatic, perineural, vascular, and pleural invasion (p <= 0.008 for all). Multivariate analysis identified male sex (p < 0.001, HR: 1.53) as a poor prognostic factor, and perineural invasion (p = 0.005, HR: 0.71), and absence of vascular invasion (p = 0.047, HR: 0.80) as independent predictors of good prognosis. Conclusion Male sex, perineural invasion, and vascular invasion were found to be independent poor prognostic factors in early-stage lung adenocarcinoma. Patients with these features should be monitored more closely and considered for adjuvant treatment strategies.