Investigation of alterations in PIK3CA and OCT-4 gene expression in breast cancer

Dirican E., Kankaya B., Buyukasik S., Alis H., Velidedeoglu M., Ilvan Ş., ...More

GENE REPORTS, vol.21, 2020 (ESCI, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21
  • Publication Date: 2020
  • Doi Number: 10.1016/j.genrep.2020.100942
  • Journal Name: GENE REPORTS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, BIOSIS, EMBASE
  • Istanbul University-Cerrahpasa Affiliated: No

Abstract

Breast cancer (BCa) is one of the most prevalent cancer amongst women and PIK3CA mutations have a crucial role in carcinogenesis. On the other hand, Octamer-Binding Transcription Factor 4 (OCT-4) is common biomarkers of cancer stem cells, which provide to the pathological processes of numerous carcinomas. In this study, we evaluated the association of OCT-4 gene expression levels with the PIK3CA mutation in BCa patients.