Investigation of alterations in PIK3CA and OCT-4 gene expression in breast cancer

Dirican E., Kankaya B., Buyukasik S., Alis H., Velidedeoglu M., Ilvan Ş., ...Daha Fazla

GENE REPORTS, cilt.21, 2020 (ESCI, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.genrep.2020.100942
  • Dergi Adı: GENE REPORTS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, BIOSIS, EMBASE
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

Breast cancer (BCa) is one of the most prevalent cancer amongst women and PIK3CA mutations have a crucial role in carcinogenesis. On the other hand, Octamer-Binding Transcription Factor 4 (OCT-4) is common biomarkers of cancer stem cells, which provide to the pathological processes of numerous carcinomas. In this study, we evaluated the association of OCT-4 gene expression levels with the PIK3CA mutation in BCa patients.